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Site rotation: Rotate injection sites systematically (abdomen at least 2 inches from navel, outer thighs, upper arms) to reduce local irritation and prevent lipohypertrophy [11]

This decrease contributes to various age-related issues, including cognitive decline, decreased energy production, and increased oxidative stress, making supplementation potentially beneficial for older adults.

Pflugers Arch 444:579585 Serman Y, Fuentealba RA, Pasten C, Rocco J, Ko BCB, Carrion F, Irarrazabal CE (2019) Emerging new role of NFAT5 in inducible nitric oxide synthase in response to hypoxia in mouse embryonic fibroblast cells