As with any blend, the position to state plainly is that the combination itself has not been studied: no published work has examined these four compounds co-administered, and no synergy among them has been demonstrated
If you are unsure, it is always better to pause and seek professional guidance
doi: 10.1186/s12906-023-03983-0 84 ZhuTZhangLLingSQianFLiYXuJ-W
VEGF Upregulation and Angiogenesis Miniaturizing follicles lose their blood supply
Petukhova L, Duvic M, Hordinsky M, Norris D, Price V, Shimomura Y, Kim H, Singh P, Lee A, Chen WV, Meyer KC, Paus R, Jahoda CA, Amos CI, Gregersen PK, Christiano AM (2010) Genome-wide association study in alopecia areata implicates both innate and adaptive immunity