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A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation

The latter finding matches the results obtained in Phox2b-Cre GLP-1 receptor KO mice, lacking GLP-1 receptors in the autonomic nervous system, which have normal body mass and composition in response to both chow and HFD [688], yet exhibit partial attenuation of the anorectic and weight loss effects of peripherally administered GLP-1R agonists [520]

10.1016/0016-5085(86)90262-3 63 NarducciF.BassottiG.GranataM

42 A double-blind crossover study from 1973 in patients complaining of tiredness found benefits of hydroxo-B12, 5000 g twice per week i.m

It can also confer kidney-protective benefits and slow the progression of kidney disease in those with type 2 diabetes, a welcome benefit as kidney disease is a common complication of the condition