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This is mechanistically different from acetylcholinesterase inhibitors or dopamine modulators: Dihexa doesn't boost existing neurotransmitter levels

Excessive mitochondrial uncoupling can lead to dangerous increases in body temperature, organ stress, and metabolic disruption

9 Further data is needed to determine the safety and efficacy of GHK-Cu for wound healing, but limited small trial data and in vitro data thus far is promising

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The review maps engineering solutions to tissue-specific delivery challenges, critically appraises evidence across primary musculoskeletal indications, and identifies translational bottlenecks separating preclinical claims from clinical reality