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26 BurkR

Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area: the possible danger of indiscriminate supplementation of iodine-deficient subjects with selenium

The former is a process characterized by mitochondrial swelling, IMM permeabilization and OMM rupture as a secondary event

This impairment compromises mitochondrial ATP production, resulting in cellular energy deficits (Siddiqui et al., 2016)

The addition of nicotinamide precursor NAM in mitochondrial respiration-impaired cells restores the lysosomal function and limits the increased proinflammatory profile