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Long-term use of NSAIDs may lead to side effects on the cardiovascular system, gastrointestinal tract, and kidneys, such as increased risks of heart disease, indigestion, gastrointestinal ulcers, bleeding, and reduced kidney function

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During cellular homeostasis, KEAP1 binds to NRF2 in the cytoplasm, leading to its rapid degradation through ubiquitination by the Cullin 3(Cul3)/ring-box 1 (RBX1) complex