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Promoting responsible behaviour among producers and consumers requires forward-thinking and collaborative decision-making, a particularly complex challenge in developing countries where adequate waste management infrastructure is lacking and awareness of 3R practices: reduce, reuse, recycle (Esposito De Vita et al., 2023

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The BACH1/NRF2 axis has been extensively studied in Down syndrome and BACH1 encoded on chromosome 21 is known to negatively regulate NRF2 [25]

Our study identified a marked increase in S100a4+ macrophages, originating from monocytes, strongly associated with fibrotic changes