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As an example, in research focusing on pancreatic ductal adenocarcinoma, Zhang et al

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The receptor expression showed dissimilar levels (at both the mRNA and protein levels) even among pancreatic cancer cells, indicating that the receptor expression was markedly variable from one cell to another (heterogeneity), and that even if there was a relationship between GLP-1R and tumor behavior, this was lost when the samples were evaluated together

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