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To examine whether activation of LS GLP-1R neurons is sufficient to suppress food intake independent of endogenous GLP-1R or exogenous liraglutide, we injected an AAV into the dLS of GLP-1R-ires-Cre mice expressing the excitatory Gq-coupled designer receptor exclusively activated by designer drugs (DREADD) hM3D-mCherry in a Cre-dependent fashion (43)

Kong, Tao [56] introduced a glutathione-sensitive nanoplatform composed of cysteine-derived poly (disulfide amide) (PDSA) nanoparticles for intracellular delivery of synthetic p53 mRNA

Tirzepatide (Injectable): Combines GLP-1 and GIP receptor activation for powerful, once-weekly appetite and blood sugar support