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The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor

The liquid chromatography (LC) gradient program was: 98% B for 1 minute, followed by a linear decrease to 40% B within 5 minutes, then maintaining 40% B for 13 minutes, then returning to 98% B in 1 minute and finally 5 minutes 98% B for column equilibration

(Erstad 2022) Unfortunately, free phenytoin level is generally a send-out test with a slow turnaround time

24 Another study by Lenton et al 25 showed that vitamin C supplements increase glutathione in human lymphocytes

This difference in localization and retention likely explains why iron chelators are less potent than ARTs against malaria parasites