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[19] [21] The compounds targeted in this manner by GSTs encompass a diverse range of environmental or otherwise exogenous toxins, including chemotherapeutic agents and other drugs, pesticides, herbicides, carcinogens, and variably-derived epoxides

While the greater amount of cellular reduced GSH is found in the cytosol and mitochondria, the endoplasmic reticulum becomes a reservoir of small concentrations of the oxidized form of GSH (GSSG)

Only if all NADPH is oxidized used to replenish GSH stores in the membrane preparations, than the determination of NADPH oxidized by GP, represents a true measurement of the specific enzyme complex [8, 9]

TGF beta mediates activation of transglutaminase 2 in response to oxidative stress that leads to protein aggregation

Consuming a variety of antioxidant-rich and sulfur-rich foods can help support natural glutathione production