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For molecules excluded from oral development, this review has surveyed realistic alternatives that deserve systematic consideration: pulmonary delivery for rapid-onset needs, nasal delivery for rescue applications, buccal/sublingual delivery for potent peptides accommodating variability, and most importantly, long-acting injectables, depots, implants, and pumps that often outperform oral approaches on pharmacokinetic predictability and total cost

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doi: 10.1053/j.gastro.2017.10.040 181 JalankaJMajorGMurrayKSinghGNowakAKurtzCet al