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Critical iron-regulatory genes that are upregulated by HIF-1, including FTH, TFR1 and DMT1, highlight the intrinsic relationship between iron metabolism and hypoxia as a fundamental aspect of cancer cell adaptation within the tumor microenvironment [88]

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Similarly, under T2D conditions the crosstalk between macrophages and -cells plays a major initiating role in establishing -cell dysfunction, and a pro-inflammatory macrophage phenotype