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The Medicines and Healthcare products Regulatory Agency (MHRA) encourages patients to inform their healthcare providers about all supplements they are taking, as interactions can occur even with 'natural' products

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Contact your healthcare provider within 24 hours if you experience: Persistent nausea or vomiting lasting more than 24 hours despite anti-nausea measures Inability to maintain adequate fluid intake for more than one day Diarrhea with more than 46 loose stools in 24 hours Consistently dark urine despite increased water intake New or worsening constipation unresponsive to increased fluids and fiber Rapid weight loss accompanied by dizziness, reduced urination, or other symptoms of dehydration Persistent headaches or dizziness affecting daily activities Seek immediate medical attention (emergency department or call 911) for: Signs of severe dehydration: confusion, extreme weakness, inability to stand, or fainting Chest pain or severe heart palpitations Severe abdominal pain, especially if accompanied by vomiting No urine output for 12 hours or longer Symptoms of acute kidney injury: decreased urination, swelling in legs or feet, severe fatigue Inability to keep down any fluids for 12 hours or more The FDA label for Zepbound specifically notes the risk of acute kidney injury in patients with renal impairment who experience severe gastrointestinal adverse reactions