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While all of the mechanisms by which GLP-1 agonists assist with weight loss are not yet fully understood, below are the well-established ways in which these injectable medications can contribute to weight loss: GLP-1s slow the release of glucagon and stimulate the secretion of insulin, thereby keeping blood sugar low

These protein structures are larger and shaped differently than the original molecule

It is available in injectable form, usually administered once a week, which offers convenience compared to daily injections required by some other diabetes medications

The minimum calorie thresholds exist for a reason

Many patients have safely reduced steroid or extra DMARD and biologic use