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Acknowledgements The authors would gratefully acknowledge the Department of Pharmaceutical Technology, Maulana Abul Kalam Azad University of Technology, West Bengal, India

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In rodent models of retinitis pigmentosa an inherited condition where light-sensing cells in the retina gradually die, leading to progressive vision loss TUDCA reduced retinal cell death and preserved photoreceptor structure and function.34 35 Other animal studies suggest benefits in models of light-induced retinal damage and diabetic retinopathy, again showing reduced apoptosis of retinal cells.25 36 TUDCA appears to protect retinal cells in several preclinical models

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Paradoxically, intragastric gavage of BTR agonists in mice was associated with only a transient increase in food intake during the first 30 min, followed by a sustained suppression of intake over the subsequent 4 h (55)