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By increasing the expression of hepcidin or suppressing FPN, IL-6 raises intracellular free iron levels, amplifying lipid peroxidation under iron-rich conditions and heightening ferroptosis (40)

KPV's small molecular weight (3 amino acids) and its derivation from a naturally occurring hormone fragment suggest a favorable safety profile, but human trial data is needed

(6) Complex I: Complex I (NADH:ubiquinone oxidoreductase) is a large multiprotein complex located in the mitochondrial inner membrane that accepts electrons from NADH and transfers them to ubiquinone (CoQ 10 ) via FMN and a series of ironsulfur (FeS) clusters, reducing it to ubiquinol (CoQ 10 H 2 ) 68,69

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Cysteine residues were searched with a static modification for carboxyamidomethylation (+57.02146 Da), and N-termini and lysine residues were searched with a static modification corresponding to the TMT tag (+229.1629 Da)