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However, network pharmacology analysis, showed that the lipid-lowering and anti-obesity effects of RRTE were closely related to the PI3K-Akt and PPAR signaling pathways

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In one of the longest published studies until today (with a follow-up of 6 years) it was clearly shown that in patients with T2D and NAFLD the severity of both steatosis and fibrosis were strongly and inversely related to the Matsuda Index of insulin sensitivity, emphasizing the crucial role of PIO (currently the most well-studied TZD) that targets IR directly to its genesis [128]

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