Surrogate Cardiometabolic Endpoints RCTs consistently demonstrate that combined SGLT2i and GLP-1RA therapy provides benefits in glycemic control, body weight, and blood pressure compared with either medication alone
However, people with certain medical conditions or those receiving B12 injections may experience negative side effects or overdose symptoms
If you're not seeing results by week 46, PlexusDx recommends discussing whether dose escalation, dietary adjustments, or switching to tirzepatide (a dual GIP/GLP-1 agonist) may be more effective for your body
Paradoxically, it also stimulates ghrelin, the hunger hormone, which can significantly increase appetite
Pausing your medication might offer the freedom to fully enjoy these experiences without concern for side effects