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While urinary excretion of VC metabolites (oxalate, threonate) maintains systemic balance, prolonged deficiency ( ShacterEet alAscorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo

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Conversely, in lung and breast cancer, elevated CHAC2 correlates with advanced tumor stage and grade, indicating a worse prognosis (Liu et al., 2017