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Nausea represents the most frequently reported gastrointestinal side effect, occurring in approximately 17-30% of patients depending on dose and indication, with higher rates typically seen at higher doses and in the weight management indication

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On the other hand, metformin-treated mice displayed a slight decrease in body weight, fat mass, and circulating glucose, insulin, and leptin levels, which was associated with a modest reduction of HOMA-IR index and a drop in daily food intake (Fig

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