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Integrative characterization of the R6/2 mouse model of Huntingtons disease reveals dysfunctional astrocyte metabolism

The results showed that the mice that experienced hypoxia for 14 days still had obvious cognitive-behavioral impairment after reoxygenation for 28 days, suggesting that the neurological damage induced by chronic hypoxia was irreversible (Fig

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Across oral, topical, intravenous (IV), intranasal, and liposomal/orobuccal routesand precursors such as Nacetylcysteine (NAC) and GlyNACevidence quality ranges from small randomized trials with surrogate outcomes to narrative reviews and case series

The LC/MS portion of the platform was based on a Surveyor HPLC and a Thermo-Finnigan LTQ Fmass spectrometer (Thermo scientific, Waltham, Massachusettes, USA), which consisted of an electrospray ionization (ESI) source and linear ion-trap (LIT) mass analyzer