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doi: 10.1016/j.advnut.2023.04.001

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These effects stem from the peptide itself, not the B12

Sublingual and buccal routes may improve this, but published data on compounded ODT bioavailability in humans is limited

The combination creates a dual mechanism: naltrexone reduces food reward and craving intensity, while bupropion enhances the brain's satiety signals and provides mild stimulant-like appetite suppression