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And the lack of clinical trial data means nobody truly knows the combined risk profile

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The add-on of DPP-4 inhibition to metformin therapy has also been the subjects of several other studies

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Most available studies are exploratory, and large, wellcontrolled randomized trials are lacking

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2021;41(7):NP866NP874

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It suppresses the livers production of VLDL (the precursor to LDL) and activates lipoprotein lipase, the enzyme that clears triglyceride-rich lipoproteins from the blood

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