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Keywords: 5 -reductase, androgen, gene mutation, gene expression, prostate 5 -REDUCTASE ISOZYMES Steroid 5 -reductase isozymes are microsomal NADPH-dependent proteins that reduce the double bond steroids at the 45 position of a variety of C 19 and C 21 including testosterone (Fig

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The mouse research that established its mechanism and preclinical effects used subcutaneous injection at a fixed research dose (20 mg/kg, three times daily) a research-animal protocol, not a human administration guide

Confirming this notion, the current results showed that nicorandil inhibited COX2 activity which contributed to its analgesic action

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