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The PDHA1 gene is located on chromosome Xp22.12 and is composed of 12 exons that generate four alternatively spliced mRNAs, each of which encodes a distinct protein isoform

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Moreover, individualized dosing strategies can help mitigate the risk of common side effects, such as nausea and gastrointestinal discomfort, which are often associated with higher doses in standard treatment protocols

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