Brattstrm L, Lindgren A, Israelsson B, Andersson A, and Hultberg B (1994)
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The protocol follows a methodical four-week escalation schedule designed to minimize gastrointestinal side effects while progressing toward therapeutic dose levels
In conclusion, metformin could ameliorate inflammation and oxidative stress in renal tubular cells, regulate apoptosis and autophagy, and attenuate tubulointerstitial damage through various mechanisms
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