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In people with T2D, retatrutide (0.5 to 12 mg) led to substantial reductions in bodyweight and HbA1c compared to both placebo and dulaglutide 1.5 mg in a phase 2 trial [67]

Current clinical evidence and medical guidance indicate that Wegovy is generally intended as a long-term treatment rather than a short-term fix

Additionally, many GLP-1 users report diminished thirst alongside reduced hunger

Therefore, based on the limited available data, it appears that the brain concentration of MCFAs may be roughly estimated to be as high as about half of their plasma concentration

Treatment is difficult and should include both pharmacologic and nonpharmacologic options