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381,382 SIRT1 has been shown to activate antioxidant pathways through the deacetylation of NRF2, thereby exerting neuroprotective effects in various PD models

Notably, the occupancy of H2AK119ub at Bdnf promoters I, II, IV, and VI was decreased, while only the occupancy of H3K27me at Bdnf II and VI was found to be reduced by BHBA in our previous study ( Bdnf promoters, or by promoting the formation of p/CAF complexes with 2A-DUB to remove the ubiquitin from H2AK119

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