Front Physiol (2017) 8:139
Methods In this retrospective cohort study, 125 474 adults with overweight or obesity newly initiated treatment with a dual-labeled GLP-1 RA (liraglutide, semaglutide, or tirzepatide) between January 1, 2018, and December 31, 2023, with a baseline body mass index of 27 or more, an available weight measurement within 60 days before initiation, and regular care in the year before initiation were identified using electronic health record data from a collective of US health care systems
This will have a whole body effect with numerous symptoms that are difficult to trace to any single illness or dysfunction
Thus, modulating the bioavailability and resorption of bile acids, the microbiota impacts on enterohepatic bile acid-signaling and greatly impacts the whole-body metabolic homeostasis (199)
Adding too much water creates a dilute solution requiring larger injection volumes