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Cross-sectional metagenomic and metabolomic cohorts consistently show a decrease in butyrate-producing taxa (e.g., Faecalibacterium, Roseburia) and an increase in mucin-degrading or pro-inflammatory genera (e.g., Akkermansia, some Enterobacteriaceae) across geographically diverse PD cohorts, with some taxa correlated with constipation, disease duration, and motor scores [57]