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1,9,10 Several drugs have been proposed for treating NASH, but according to the guidelines of European and American societies, metformin (an insulin sensitizer) is not recommended because it showed no effect on liver histology although it has a beneficial effect on insulin resistance and alanine aminotransferase (ALT) levels

Figure 1 3.1.2 Preparation process of DOXHCl solution In the prescription study, it was found that doxycycline hyclate dissolved incompletely when the solution was prepared at room temperature, indicating that the preparation of the product required certain heating conditions

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Consistency provides stability during a period of pharmacological change

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