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223 Recently, a study found that alpha-TC1/6 cells can secrete GLP-1 under hyperglycemic, hyperlipidemic or inflammatory conditions during in vitro experiments, suggesting that this hormone may act locally to influence both islet alpha- and beta-cell behaviour during pathological conditions

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Similarly, Figures 5G and H show that PNP-1-10-0.05 Sema-1.8 mg/mL hydrogel resulted in sustained glucose lowering compared to the bolus injection, maintaining efficacy across the cohort