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In an AD amyloid mouse model lacking BACE1 palmitoylation, reduced BACE1-containing localization within dystrophic neuronal synapses around amyloid plaques led to a significant reduction in local amyloid load, which alleviated cognitive dysfunction in mice (169)

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ADM (Acquired Dermal Melanocytosis) ADM, or Acquired Dermal Melanocytosis, appears symmetrically on both sides of the cheeks and forehead