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Separately, researchers compiled over 31.7 Gbp of transcriptomic data from various tissues and developmental stages of A

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Based on this mechanism, HDAC5 downregulation protects renal function by inhibiting neutrophil accumulation, decreasing the expression of AKI markers kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL), and downregulating pro-caspase 1, active caspase 1, and IL-1 expression to mitigate tubular cell damage (Sharma et al., 2022)

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