Recent research has demonstrated that elevated expression of ferroptosis-suppressor genes GPX4, FTH1, and FTL, correlates with reduced 5-year overall survival in male CRC patients harboring KRAS mutations [171]
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Neurological manifestations are particularly concerning and may include peripheral neuropathy with paresthesias (tingling and numbness in hands and feet), ataxia, impaired proprioception and vibratory sense, cognitive impairment, memory loss, and in severe cases, subacute combined degeneration of the spinal cord
Resveratrol is a polyphenol with antioxidant effects, while pterostilbene offers similar benefits with better absorption