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10.1001/jama.2018.3024 Summary Keywords semaglutide, tirzepatide, dulaglutide, liraglutide, GLP-1 (Glucagon-Like Peptide 1), HbA1c, type 2 diabetes mellitus, randomized controlled trials Citation Karimi MA, Gholami Chahkand MS, Dadkhah PA, Sheikhzadeh F, Yaghoubi S, Esmaeilpour Moallem F, Deyhimi MS, Arab Bafrani M, Shahrokhi M and Nasrollahizadeh A (2025) Comparative effectiveness of semaglutide versus liraglutide, dulaglutide or tirzepatide: a systematic review and meta-analysis

Ozempic has also shown promise as a weight-loss medication and is often prescribed off-label for this purpose

Stewart, A

Both medicines support metabolic health and structured weight management

You may also notice a rapid decrease in your appetite and a reduction in food cravings as the medication begins to take effect