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The treatment plates included NGM + 0.5% (v/v) DMSO (vehicle control, Ctl), NGM + 250 M SIH, and NGM + 200 M Lip-1 (as described above)

For researchers focused on fat loss applications , understanding this dual mechanism explains why cagrilintide alone produces meaningful but moderate weight loss (around 11.8% in phase 3 data), while the combination pushes results dramatically higher

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