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This circuit originates from the DLPFC, projects to the new striatum and thalamus, and then loops back to the cortex, primarily involving the limbic system, cortex, striatum, white matter, and thalamus (Tekin and Cummings, 2002)

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Kidney and Hydration-Focused Evaluation Kidney-focused testing may be particularly relevant when there is: Persistent vomiting or diarrhea Reduced fluid intake Low urine output A history of chronic kidney disease Diabetes or high blood pressure Use of other medications that influence kidney function or fluid balance A Comprehensive Metabolic Panel (CMP) provides creatinine, estimated glomerular filtration rate, BUN, and electrolytes

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Available from: Accessed 6/24/2026