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95 HironoN.MoriE.IshiiK.IkejiriY.ImamuraT.ShimomuraT.et al (1998)

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Its narrow, fragment-specific mechanism makes it a frequent comparison point in studies exploring how isolated peptide regions behave differently from their parent hormone a topic covered in more depth in our roundup of best peptides for fat loss research

Melasma develops due to several factors: Hormonal changes (pregnancy, oral contraceptives) Genetic predisposition Skin inflammation or irritation Certain medications Cosmetic products Heat and UV exposure Excessive sun exposure Sun exposure remains the strongest trigger , making sunscreen essential in treatment