Y.SaimaitiA.et al (2022)
These improvements can enhance endurance, physical function, and overall fitness
Rubino F, Cummings DE, Eckel RH, et al
In the field of delivery technology, targeting the unique joint anatomy and pathological environment of OA, developing biodegradable sustained-release carriers such as smart responsive nanogels, porous microspheres, or tissue engineering scaffolds is key to achieving long-term and controlled release of GPX4 genes, regulatory miRNAs or ASOs, or small molecule ferroptosis inhibitors at the lesion site ( Considering the multifactorial pathogenesis of OA, future research needs to prioritize conducting early proof-of-concept clinical trials to evaluate the feasibility and synergistic effects of locally applied ferroptosis inhibitors such as Fer-1 or GPX4 activators combined with existing conservative treatments including weight management, physical therapy, and NSAIDs or emerging cell and tissue engineering therapies
These broader benefits apply regardless of whether you are at the starting dose or the maximum