instead of being a single GLP-1 receptor agonist like semaglutide, tirzepatide is a GLP-1/glucose insulinotropic peptide (GIP) dual agonist, which explains the greater weight loss it delivers
On the other hand, it can alleviate mitochondrial oxidative stress via the activation of Nrf2, Sirtuin-1 and Sirtuin-3 (Molina-Jijn et al., 2011
Designing a dual GLP-1R/GIPR agonist from Tirzepatide: comparing residues between Tirzepatide, GLP-1, and GIP
Ingky, a practising dermatologist and skincare educator with extensive clinical experience in pigmentation management, and Geraldyn Low, a pharmacist trained at the University of Strathclyde
Khan, MD, University of Pittsburgh Medical Center Once-weekly semaglutide in adults with overweight or obesity, The New England Journal of Medicine (2021) Semaglutide for Type 2 diabetes mellitus: A systematic review and meta-analysis, Diabetes, Obesity and Metabolism (2018) About Dr