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The therapeutic role of GSH in NAFLD As already mentioned, oxidative stress is a pathophysiological hall-mark of metabolic liver disease ( While several clinical studies examined the favorable effect of reduced GSH short-term or long-term administration on alcohol-induced liver diseases (Table 1-, and the studies at hand are to be considered pilots ( Table 1 Main studies on the role of reduced glutathione (GSH) treatment in patients with metabolic liver disease