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The most popular hypothesis is that sporadic PD is due to an interplay between genetic and environmental aetiological factors, which in turn lead to alterations in the mitochondrial, lysosomal, and inflammatory pathways, among others, leading to eventual neuronal cell death

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Named for its ability to promote slow-wave (delta) sleep in experimental animals, DSIP has been studied for its roles in sleep regulation, stress response, and pain modulation