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Given that E2 and E4 alleles are associated with vascular diseases (Belloy et al., 2019) and both GBB and crotonobetaine have been associated with vascular disease (Koeth et al., 2014, 2019

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As the American Diabetes Association's Standards of Medical Care in Diabetes (2024) states regarding injection devices, "The smallest available needle should be used to minimize patient discomfort, and correct injection technique should be taught and reinforced at every clinical encounter" [13]