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All work is non-clinical and mechanistic in nature

In the early 20th century it was noted to lower blood glucose concentrations in animals, but it was not until the 1950s that Jean Sterne studied dimethylbiguanide and subsequently developed Glucophage [2]

Disclaimer: Compounded medications are not FDA-approved drug products

Markers of apoptosis, including elevated Bax and caspase-3 along with reduced Bcl-2, were significantly dysregulated in the STZ-induced diabetic group in this study, indicating enhanced pro-apoptotic signaling and mitochondrial dysfunction 55,56

GLP-1s in Action What have GLP-1s been effective in treating (aside from obesity in general)