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These different results could be accounted for by both the expression of NADPH oxidase induced by KRAS G12D overexpression, which leads to ROS generation, and an increase in NRF2-dependent ROS scavenging in cells expressing physiological levels of KRAS G12D

Nutrients (2021) 13:523

This depletion appears to correlate with disease progression and severity, suggesting oxidative imbalance may be both a consequence and contributor to neurodegeneration

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