This may be due to copper's ability to enhance the expression of metalloproteinases (MMPs).16 MMPs normally regulate the degradation of collagen, and a specific one, MMP-1, may be responsible for the initiation of collagen fragmentation.17 Supporting this, a 2024 study noted that elevated MMP-1 levels appear to contribute to aging skin and that higher MMP-1 levels in mice led to:18 The loss and fragmentation of dermal collagen fibrils Contracted fibroblast morphology Reduced collagen production Increased expression of pro-inflammatory mediators Additionally, a 2016 study found that GHK-Cu significantly increased gene expression of MMP-1 and MMP-2 at the lowest concentration, which the studys authors considered to be one of the reasons the peptide was able to increase collagen and elastin production.19 So, what this could ultimately mean is that using too much GHK-Cu (or other copper peptides) may in theory increase the skins MMP-1 concentration above the levels involved in healthy collagen production, taking it into the collagen fragmentation and breakdown territory seen in older skin with naturally higher MMP-1 levels

We often recommend peptides for: Chronic pain and inflammation Post-surgical recovery (to speed healing and reduce downtime) Skin rejuvenation and hair restoration Muscle and joint recovery (ideal for high-performers and athletes) Strength gains and muscle optimization Weight loss and metabolic reset Hormone balancing (including growth hormone and testosterone support) Improved sleep, mental clarity, and memory Fatigue and low energy Our approach is never one-size-fits-all
Product Specifications Reconstitution Add 2ml of bacteriostatic water to the lyophilised blend
The peptide preserves mitochondrial integrity by protecting against superoxide radical accumulation in mitochondrial compartments, maintaining efficient energy production and preventing mitochondrial-derived oxidative stress
This process, called cellular respiration, depends entirely on NAD+ availability