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Nocturnal hypoglycaemia may occur when tirzepatide is used with insulin or sulfonylureas, potentially causing night-time awakenings and sweating

The combination of reduced caloric intake (from tirzepatide appetite suppression) and enhanced fat breakdown (from AOD 9604 lipolysis) creates a steeper downward trajectory

Hair loss concerns are less documented with retatrutide than with some other GLP-1 agonists, but the rapid weight loss itself can trigger telogen effluvium, a temporary shedding condition

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They also possess a lower glycemic index, contributing to the maintenance of consistent blood sugar levels