3.3 Antioxidant interventions for the preservation of ovarian tissue and oocyte in the context of in vitro fertilization Oxidative stress triggers apoptosis in granulosa cells, leading to the upregulation of pro-apoptotic factors and the downregulation of anti-apoptotic proteins, ultimately causing ovarian tissue damage and follicular depletion ( Table 1 (82, 83)
Why Glutathione Cannot Lighten Hair Even though glutathione can influence skin pigmentation, it does not have the same effect on hair because: Hair outside the scalp is non-living tissue
Tamura H, Jozaki M, Tanabe M, et al
Both are healing peptides, but they work through different mechanisms
In addition, since some studies have also recorded failure in antioxidant supplementation efficacy, optimal design of clinical trials in terms of targeted delivery of antioxidants, clinical pathology and concentration dependent dosage schedule is needed to go ahead in the knowledge and future application of this kind of treatment in CIPN (Kamat et al., Future consideration Taking in account the scientific evidence summarized in this review, NP is a complex network of several molecular processes, including nitro-oxidative stress, immune response, and TRP channels activation, among others
